Elevated levels can occur because the diseased kidneys are not able to properly filter and remove excess vitamin B12 from the bloodstream. Bakker, a professor of internal medicine at the University Medical Center Groningen in the Netherlands. An increased blood level of vitamin B12 is sometimes caused by kidney disease, including diabetic kidney disease. A high level indicates a true B12 deficiency. With alcoholic liver disease, vitamin B12 as well as its carrier proteins can be elevated. The second set was done 9 months later when he was completely healthy. 2010;91(5):1255-1260. doi:10.3945/ajcn.2009.29094, Salehpour A, Hosseinpanah F, Shidfar F, et al. Rarely, a high level of vitamin B12 may be caused by diabetes or obesity, according to WebMD. 2013;32(3):375-381. doi:10.1016/j.clnu.2012.08.014, Marcinowska-Suchowierska E, Kupisz-Urbańska M, Łukaszkiewicz J, Płudowski P, Jones G. Vitamin D Toxicity-A Clinical Perspective. High vitamin B12 means levels are higher than 1,500 picograms per milliliter. Optimal vitamin D status for colorectal cancer prevention: a quantitative meta analysis. High levels of vitamin B12 in a person's blood are associated with an increased risk of early death, according to research published last month in the journal JAMA Network Open. Because vitamin B12 helps make red blood cells and keeps your nerves working properly, it’s reassuring to know that most people don’t need to worry about having too much, or too little, in their system. It is possible, based on certain conditions, that a vitamin B12 test may be inconclusive or incorrect, claims WebMD. 2011;96(7):1911-1930. doi:10.1210/jc.2011-0385. Take all high-dose B12 supplements, B12 injections, and B12 nasal gel under direct supervision of a health care provider (especially if you're taking medications) and report any side effects to your doctor immediately. Figures above 900 pg/ml are considered high, but certain cases have recorded four or even five figure values. Since B12 is a water-soluble vitamin, it’s generally considered safe, even at high doses. Permanent nerve damage can occur if vitamin B12 deficiency is not treated. The reasons are unclear. My 10 year old son had some blood work repeated from when he was in the ER with chest pain. Arch Intern Med. When taken at appropriate doses, vitamin B-12 supplements are generally considered safe. While it may be possible to get too much vitamin B-12, overdosing on the vitamin is very rare. Vitamin B12 is a commonly used supplement and has been tested as a preventive treatment for Alzheimer’s disease, but could too much of it be bad for you? Heaney, Robert P. “The Vitamin D Requirement in Health and Disease.” The Journal of Steroid Biochemistry & Molecular Biology 97 (2005):13-9. Public Health Nutr. High vitamin B12 and blood disorders High vitamin B12 is frequently observed in myeloproliferative disorders (CML, PV, MF) A statistically significant association was found between vitamin B12 levels >1275 pg/ml and haematological malignancies. Other cancers that might cause: It is thought that excess production of vitamin B12 carrier proteins by the tumors is the primary culprit for elevated levels. It was long thought that high vitamin B12 levels weren’t harmful, but a significant number of emerging studies have linked high B12 blood levels and B12 supplementation to higher … Deficiency should be confirmed by checking the level of a substance in the blood called methylmalonic acid. One in the 1800s and one 1700s. A person with vitamin B12 deficiency may feel weak and fatigued. There is also a condition where a person has too many white blood cells … The low range of what’s considered normal B12 blood levels in most countries (100-250) is way too low, often missing desperately deficient folks. Older adults who have a vitamin B12 deficiency will likely have to take a daily B12 supplement or a multivitamin that contains B12. Folate (>3.0 ng/mL) 14.3. On top of that, we know that only a small percentage of vitamin B12 taken orally is actually absorbed. A 12-week double-blind randomized clinical trial of vitamin D₃ supplementation on body fat mass in healthy overweight and obese women. The main dietary sources of vitamin B12 include meat, dairy and fish. While the recommended daily amount of vitamin B-12 for adults is 2.4 micrograms, you can safely take higher doses. Dizziness 2. 2007;32(3):210-216. doi:10.1016/j.amepre.2006.11.004, Lappe JM, Travers-Gustafson D, Davies KM, Recker RR, Heaney RP. High vitamin B12 levels are associated with many blood diseases, including various types of leukemia and related blood disorders. This makes it nearly impossible to overdose on the nutrient. 2010 91:1255-60. 2009; 169:384-90. I have been on vitiligo treatment for last 2 months and as a part of the treatment am taking patchex tablet eveeyday which has b12 along with other multi vitamins and herbal extracts. My doctor's office called and said my levels were fine, but why would my B12 level be high if I am not taking B12 supplements? Holick MF. Agency for Healthcare Research and Quality. Older adults with a vitamin B12 level less than 100 pg/mL (74 pmol/L) may also have symptoms. Salehpour A1, Hosseinpanah F, Shidfar F, Vafa M, Razaghi M, Dehghani S, Hoshiarrad A, Gohari M. A 12-week Double-blind Randomized Clinical Trial of Vitamin D₃ Supplementation on Body Fat Mass in Healthy Overweight and Obese Women. For example, a damaged liver may release the vitamin out of storage and into the blood. Hematologic disorders like chronic myelogeneous leukemia, promyelocytic leukemia, polycythemia vera and also the hypereosinophilic syndrome can result in elevated levels of cobalamin. However, high levels of vitamin B12 can indicate serious health problems. Epub 2012 Aug 31. Headache 3. Researchers in the Netherlands measured B12 levels in 5,571 generally healthy men and women whose average age was 54. It increases the risk of heart disease. "what does a high level of vitamin b12 do to me?" High levels of Vitamin B12 may be too much of a good thing. They have had several blood tests done. High blood B12 levels can occur in liver conditions such as cirrhosis and hepatitis. The liver might also be unable to sufficiently remove enough vitamin B12 or its carrier protein from the blood. Folate (>3.0 ng/mL) 14.3. 2008;4(4):827-836. doi:10.2147/tcrm.s3552, Giovannucci E, Liu Y, Hollis BW, Rimm EB. Causes of Vitamin B12 Overdose. doi:10.1210/jc.2013-1195. A June 2013 review article published in the "Quarterly Journal of Medicine" reported that high vitamin B12 levels most commonly occur with liver cancer. Health Effects of High Levels. High Vitamin B12 levels when taking supplements are irrelevant and there is no need to discontinue them if you do not want to and are not experiencing problems from them. Vitamin B12 levels are measured through a vitamin B12 level blood test, also referred to as a cobalamin test, according to MedlinePlus. Vitamin D (30-100.0 ng/mL) 36.8. Your body absorbs only as much as it needs, and any excess passes through your urine.High doses of vitamin B-12, such as those used to treat a deficiency, might cause: 1. With cirrhosis, the severely damaged liver typically can no longer store B12, leading to high blood levels. In the January 3 JAMA Network Open, scientists led by Jose Flores-Guerrero and Stephan Bakker, University of Groningen, the Netherlands, reported that people who have high levels of the vitamin in their blood are more likely to … Arch Intern Med. Urashima M, Segawa T, Okazaki M, Kurihara M, Wada Y, Ida H. Randomized Trial of Vitamin D Supplementation to Prevent Seasonal Influenza A in Schoolchildren. “A high B12 reading could indicate a methylation issue which causes the B12 to “pool” in one’s system because it can not be broken down and used properly. Hence, we might have included persons with high plasma B12 levels due to use of over-the-counter high-dose B12 drugs in the high B12 groups. Vitamin B12 is an essential nutrient, important in nerve and blood cell health, and most people obtain enough of it in food. Significantly more cases with high B12 levels “I’ve been a psychiatrist for 25 years and have wondered for years why my patients with autism have such high B12 levels, even though they haven’t taken vitamin supplements. It was long thought that high vitamin B12 levels weren’t harmful, but a significant number of emerging studies have linked high B12 blood levels and B12 supplementation to … There is a low-cost blood test available that can detect this genetic defect. Causes of High Blood Levels of Vitamin B12 Excess Vitamin Supplements. In reply to @emyliander "I too have had two B12 labs done. It appears that the more important question to be answered when you have high vitamin B12 levels is WHY you have high B12 as opposed to whether having too much of this vitamin can be toxic. High vitamin B12 levels could also be explained by elevated vitamin B12 binding protein levels that are not filtered properly by the kidneys. High levels of Vitamin B12 may be too much of a good thing. Excessive levels of B12, he said, “might change the gut microbiota in ways that could be harmful — no one really knows.”, Still, Dr. Bakker said, “Our finding was only an association” and could not prove “a cause-and-effect relationship.”. High Vitamin B12 levels when you are NOT taking supplements are a different story and almost certainly indicate that you have the MTHFR Gene Mutation B12 levels too high Vitamin B12, or cobalamin, is important for the development of healthy red blood cells and proper nervous system function. It is extremely rare to have a high blood level from too much vitamin B12 in the diet. The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. Increased vitamin B12 levels are uncommon, because excess vitamin B12 is usually eliminated with urine. Cardiovascular Health. High B12 levels in the blood can be the result of liver disease, kidney failure and blood cancers. Some people with various conditions find that they need many milligrams daily, either by injections, sublinguals, etc. It is possible, based on certain conditions, that a vitamin B12 test may be inconclusive or incorrect, claims WebMD. Vitamin B12 (211-946 pg/mL) 1053. 2011;96(1):53-58. doi:10.1210/jc.2010-2704, Bouillon R, Van Schoor NM, Gielen E, et al. It is important to carefully monitor how much vitamin B-12 you take to ensure that you do not take too much or too little. the 3 year old daughter of a dear friend was recently diagnosed with peripheral neuropathy. Carrillo AE1, Flynn MG, Pinkston C, Markofski MM, Jiang Y, Donkin SS, Teegarden D. Impact of Vitamin D Supplementation During a Resistance Training Intervention on Body Composition, Muscle Function, and Glucose Tolerance in Overweight and Obese Adults. Am J Clin Nutr. There are a few different ways kidney disease is thought to contribute to high blood vitamin B12 levels. She has trained at the University of Virginia Medical Laboratories and has over 15 years experience in clinical, cancer and immunology research. Disregard blood vitamin B12 levels and go by symptoms alone. Nutr J. Significantly, the authors noted in their study that high plasma Cbl levels are probably not related to a patient’s consumption of foods or dietary supplements containing vitamin B12, as intake does not substantially increase levels in the blood. I would love to hear from you. Both sets revealed high Hematocrit and Hemaglobin counts and the second set also had a test for B12. Persons with low B12 levels were excluded together with persons with cancer … One of the main causes of increased vitamin B12 with liver disease is release of stored vitamin by liver cells that have died due to the disorder. Copyright © 2021 Leaf Group Ltd., all rights reserved. Vitamin D: Dietary Supplement Fact Sheet. Which is very high. Not surprisingly, a r … Nausea 5. Answered by Dr. Thomas Namey: Nothing. If you have high blood levels of B12 there are two possible causes, with different solutions… 1. if you consume a lot of B12 supplements then stop taking those supplements. 2013;98(8):E1283-E1304. 2007;85(6):1586-1591. doi:10.1093/ajcn/85.6.1586, Prentice RL, Pettinger MB, Jackson RD, et al. Her symptoms are painful tingling in finger and toes. I thought this was really strange,” says Hope. Ther Clin Risk Manag. My 10 year old son had some blood work repeated from when he was in the ER with chest pain. An increased blood level of vitamin B12 is sometimes caused by kidney disease, including diabetic kidney disease. Those with B12 deficiency, or an inability to absorb it, can use supplements. Modern Nutrition in Health and Disease, 9th ed. Today I got my B12 levels checked and it came Out to be > 2000. Chronic myeloid leukemia is one such disease, in which the elevated vitamin B12 levels are thought to be due to release of excess B12 carrier proteins from the cancerous white blood cells. This includes swelling of the face, tongue, and throat, and difficulty swallowing and breathing. Clinically, it can be paradoxically accompanied by signs of deficiency, reflecting a functional deficiency linked to qualitative abnormalities, which are related to defects in tissue uptake and action of vitamin B12. Vitamin B12 is generally not present in plant foods, but fortified breakfast cereals are a readily available source of vitamin B12 with high bioavailability for vegetarians [5,13-15]. Am J Prev Med. Cannell JJ, Vieth R, Umhau JC, et al. Vitamin B12 is naturally found in animal products, including fish, meat, poultry, eggs, milk, and milk products. Photo courtesy of Shutterstock . High levels of homocysteine have an impact on the heart. 2012 Sep 22;11:78. doi: 10.1186/1475-2891-11-78. J Clin Endocrinol Metab. I too have had two B12 labs done. Since vitamins, by definition, are substances that we cannot make ourselves, a high level can only come from high intake. And shouldn't I have a higher level of Vitamin D? Healthy Skin And Associated Structures Hematologic disorders like chronic myelogeneous leukemia, promyelocytic leukemia, polycythemia vera and also the hypereosinophilic syndrome can result in elevated levels of cobalamin. Learn more here. Supplement too high: High B12 level can be related to taking too much B12 supplements; most of time excess is excreted because being water soluble vitamin.In rare cases, e ... Read More 0 1 doctor answer. Because of the low toxicity of vitamin B 12, no tolerable upper intake level (UL) has been set by the US Food and Nutrition Board.” It is, however, important to note that too much B12 may cause issues in certain cases. Osteoporos Int. Vitamin B12 Test and Extremely High Blood Levels Whilst low blood levels of vitamin B12 indicate deficiency in a test ; elevated blood levels are also often discovered. High vitamin B12 means levels are higher than 1,500 picograms per milliliter. Vitamin B12 is considered to be very safe. Front Endocrinol. 2008;168(11):1174-1180. doi:10.1001/archinte.168.11.1174, Gorham ED, Garland CF, Garland FC, et al. University of Ottawa Evidence-based Practice Center. Vitamin B12 is an essential nutrient, useful for maintaining blood and nerve health, and can be found in foods like sardines and eggs.. ... Hello @annieecruz. Moreover, preliminary evidence suggests that high serum folate levels might not only mask vitamin B12 deficiency, but could also exacerbate the anemia and worsen the cognitive symptoms associated with vitamin B12 deficiency [6,11]. My vitamin b12 Level is too high. Epidemic Influenza and Vitamin D. Epidemiol Infect. “High amounts of vitamin B12 are often taken without a medical indication,” said the senior author, Dr. Stephan J.L. The earlier you begin treatment, the more likely you are to avoid permanent damage. Position Statement of Vitamin D. 2010. Vitamin B12 lowers the level of homocysteine. Levels of serum vitamin B12 may be raised in: While vitamin B12 is generally not considered toxic in high levels, it's important to determine if the elevation is due to excess vitamin supplements since other causes of a high vitamin B12 level are usually serious. Normal vitamin B12 levels … 2015;18(3):379-391. doi:10.1017/S1368980014000457, Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Wilkins, Consuelo H. and Yvette I. Sheline, et al. 2006; 134:1129-40. Nutr J. Effectiveness and Safety of Vitamin D in Relation to Bone Health. Dr. Mikesh performed kidney and bone marrow transplantation compatibility testing to put herself through graduate school. Baltimore: Williams and Wilkins, 1999. Causes of vitamin B12 deficiency include: Not enough vitamin B12 in diet (rare, except with a strict vegetarian diet) Diseases that cause malabsorption (for example, celiac disease and Crohn disease) Lack of intrinsic factor, a protein that helps the intestine absorb vitamin B12 Vitamin B12 is a water-soluble vitamin, which means that when we ingest too much of it, the excess amounts are flushed out of the body through urine. This makes it nearly impossible to overdose on the nutrient. Vitamin D. In: Shils M, Olson J, Shike M, Ross AC, ed. Health risks and benefits from calcium and vitamin D supplementation: Women’s Health Initiative clinical trial and cohort study. High Vitamin B12 levels when you are NOT taking supplements are a different story and almost certainly indicate that you have the MTHFR Gene Mutation: B12 levels too high by: Anonymous Thank you for your comments on high vit b12. 2. Pregnancy or breast feeding may also affect the outcome of a vitamin B12 test. The most obvious cause of an elevated vitamin B12 level is taking too much of the vitamin in the form of supplements. For most people, treatment resolves the problem. There are no adverse affects from taking high doses vitamin B12. On top of that, we know that only a small percentage of vitamin B12 taken orally is actually absorbed. High vitamin B12 levels could also be explained by elevated vitamin B12 binding protein levels that are not filtered properly by the kidneys. No Tolerable Upper Intake Level (UL) has been established for B12, due to its low level of toxicity. 2007 Mar;32(3):210-6. Vitamin B12 (211-946 pg/mL) 1053. is a blood b12 level of 1400 too high? When high doses of vitamin B 12 are given orally, only a small percentage can be absorbed, which may explain the low toxicity. 2008; 168:1174-80. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. None were taking supplements. Vitamin B12 is a water-soluble vitamin, which means that when we ingest too much of it, the excess amounts are flushed out of the body through urine. Gorham ED, Garland CF, Garland FC, Grant WB, Mohr SB, Lipkin M, Newmark HL, Giovannucci E, Wei M, Holick MF. An elevated vitamin B12 level can be a nonspecific indicator of several types of solid organ cancer. Background: Elevated vitamin B12 levels (B12) are associated with increased short-term cancer risk. Because the body doesn't store the nutrient, high B12 symptoms are rare. “Vitamin D Deficiency Is Associated with Low Mood and Worse Cognitive Performance in Older Adults.” American Journal of Geriatric Psychiatry 14 (2006): 1032-40. Patient Guide to Vitamin D Deficiency. The elevated B12 levels in myeloid neoplasms are primarily linked to the increased production The liver is the main storage and clearance site for vitamin B12. 2012;11:78. doi:10.1186/1475-2891-11-78, Carrillo AE, Flynn MG, Pinkston C, et al. An elevated vitamin B12 level can be a nonspecific indicator of several types of solid organ cancer. Vitamin B12, which is commonly found in a variety of foods, including fish, meat, eggs, and dairy products, is essential for maintaining the health of the body's nerve and blood cells — it also helps make DNA. While doctors are often more concerned with low vitamin B12 levels, high levels might also signal a serious medical problem. Taking certain medications, for instance, may affect the test results. Wait too long, and permanent neurological damage may occur. If you have high blood levels of B12 there are two possible causes, with different solutions… 1. if you consume a lot of B12 supplements then stop taking those supplements. Vitamin D deficiency in minority populations. People show symptoms of B12 deficiency even in higher levels, as deficiencies begin to appear in the cerebrospinal fluid below 550. Am J Prev Med. However, the implications for early cancer detection in primary care have not been assessed. A high level of vitamin B12 in the blood can be caused by liver disease or myeloproliferative disorders, according to MedlinePlus. They followed them for an average of eight years. With alcoholic liver disease, vitamin B12 as well as its carrier proteins can be elevated. Very high blood levels of vitamin B12 were tied to an increased risk of early death. But a study in JAMA Network Open suggests that very high blood levels of vitamin B12 may be life-threatening. Vitamin B-12 can cause very rare but serious allergic reactions (anaphylaxis). High vitamin B12 levels are not associated with any particular symptoms. The high frequency of high serum cobalamin was recently exemplified in a retrospective study by Deneuville et al., which included 3702 hospitalized patients in whom high levels of vitamin B12 were found in 12% of cases, whereas a deficiency was only observed in 10% of cases. The most common diseases associated with high levels of the vitamin are kidney failure, blood cancers, leukemia, liver disease, polycythemia vera, and hypereosinophilic syndrome. Ginde AA, Mansbach JM, Camargo CA, Jr. Association Between Serum 25-Hydroxyvitamin D Level and Upper Respiratory Tract Infection in the Third National Health and Nutrition Examination Survey. My doctor's office called and said my levels were fine, but why would my B12 level be high if I am not taking B12 supplements? Elevated homocysteine might increase your risk of diseases of the heart and blood vessels (cardiovascular disease). I am not aware of any disease process that results in high levels of b12. The researchers found that death rates were almost twice as high in those in the highest one-quarter for B12 levels as for those in the lowest. 2013;24(2):567-580. doi:10.1007/s00198-012-2224-2, Urashima M, Segawa T, Okazaki M, Kurihara M, Wada Y, Ida H. Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren. What to Do If Your B12 Is Too High | Livestrong.com High Serum B12 Can Be Caused By A Functional B12 … Mine is high, 1637, but do take 2000 mcg daily. Hypercobalaminemia (high serum vitamin B12 levels) is a frequent and underestimated anomaly. Clin Nutr. No point in paying for an Active B12 test with serum B12 levels that high, only worth it if in the so called grey area (under 400). J Clin Endocrinol Metab. Thank you. Aug 2007: 07-E013. If you have elevated vitamin B12 levels in your bloodstream, it is a sign of a serious illness. According to a September 2012 study in "PLoS One," people with high vitamin B12 had a 4- to 18-times higher risk of having a blood disease. High Cbl levels result from unknown causes, possibly some kind of malignant process. The use of calcium and vitamin D in the management of osteoporosis. High vitamin B12 is a symptom of an underlying illness that causes the amount in your blood to increase. Researchers in Denmark have found higher than normal levels of vitamin B12 may indicate a person is at risk of developing certain cancers. The cause of the high level with these diseases is similarly thought to be due to an increase in the vitamin B12 carrier protein. Methods: Individuals with plasma B12 measurements were sampled from The Health Improvement Network primary care database, UK. So clearly if you have high B12, you need to get to the bottom of why this is. Vitamin D (30-100.0 ng/mL) 36.8. 2 years ago my levels were low, 158. dr referring me to hematologist. You can’t overdose on B12, and the risk is just too high. J Clin Endocrinol Metab. Anxiety 4. Optimal vitamin D status: a critical analysis on the basis of evidence-based medicine. Becoming deficient in B-12 is a much more common health problem. If that is the case, then stop taking them and/or reduce the doses. Clin Nutr. // Leaf Group Lifestyle, Holick MF, Gordon CM. Can high doses of B12 be toxic? Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial. Taksler GB, Cutler DM, Giovannucci E, Keating NL. Parents are very concerned, as there are not many answers that their dr. can give to them. If you have elevated vitamin B12 levels in your bloodstream, it is a sign of a serious illness. Taking vitamin B12 at levels close to the RDA as part of a multivitamin supplement and eating B12-rich foods likely won't lead to side effects. 25-hydroxyvitamin D and risk of myocardial infarction in men: a prospective study. Giovannucci E, Liu Y, Hollis BW, Rimm EB. National Institutes of Health Office of Dietary Supplements. Dizziness, anxiety, headache and nausea are potential signs of elevated B12 levels. Vitamin B12 is an essential nutrient, important in nerve and blood cell health, and most people obtain enough of it in food. Vitamin B12 helps in improving energy levels. She also has an elevated level of vitamin B12 (1600). Vitamin B12 is an essential nutrient, important in nerve and blood cell health, and most people obtain enough of it … Vitamin B12 is not very tox ... Read More. 2018;9:550. doi:10.3389/fendo.2018.00550, Ross AC, Manson JE, Abrams SA, et al. Thank you. Epub 2010 Mar 10. It has been a while since you first posted about High B12 levels and I was wondering if you ever found an explanation for this? Taking certain medications, for instance, may affect the test results. The most obvious cause of an elevated vitamin B12 level is taking too much of the vitamin in... Leukemia and Related Blood Diseases. High vitamin B12 levels are associated with many blood diseases, including various types of leukemia and related blood disorders. mine was 11,500! Leann Mikesh holds a Ph.D. in pathology. Many vitamin B-12 supplements contain much more of the vitamin than the body needs. Both sets revealed high Hematocrit and Hemaglobin counts and the second set also had a test for B12. 2011;96(7):1-2. doi:10.1210/jcem.96.7.zeg33a, Sunyecz JA. American Academy of Dermatology. The Journal of Clinical Endocrinology & Metabolism. I cannot imagine any way to have B12 levels that are too high except by taking very large amounts of supplements or B12 injections. Consuming large amounts of the vitamin won’t make you sick. This author has been verfied for credibility and expertise. Alcoholic liver disease is an example of a liver condition associated with high vitamin B12. Arch Intern Med. The American Journal of Clinical Nutrition. The most common diseases associated with high levels of the vitamin are kidney failure, blood cancers, leukemia, liver disease, polycythemia vera, and hypereosinophilic syndrome. Vomiting what causes extremely high serum vit b12 levels? 2. The liver is the main storage and clearance site for vitamin B12. Am J Clin Nutr. Elevated levels of serum cobalamin may be a sign of a serious, even life-threatening, disease. With cancers involving the liver, there can also be a buildup of vitamin B12 in the blood due to decreased clearance by the diseased liver. The study controlled for many factors that might affect mortality, including age, sex, body mass index, tobacco and alcohol use, diabetes, cancer and cardiovascular disease, as well as markers of liver and kidney function. In reply to @ emyliander vitamin B-12 supplements are generally considered safe even!, a damaged liver may release the vitamin out of storage and clearance site for vitamin B12 as well its. ):210-216. doi:10.1016/j.amepre.2006.11.004, Lappe JM, Travers-Gustafson D, Davies KM, Recker,! Occur if vitamin B12 may be caused by liver disease or myeloproliferative disorders, according MedlinePlus. Medical Center Groningen in the Netherlands measured B12 levels ( B12 ) are associated many. Damaged liver typically can no longer store B12, or an inability to absorb it can. A daily B12 supplement or a multivitamin that contains B12 while the daily... Both sets revealed high Hematocrit and Hemaglobin counts and the risk is too... Vitamin than the body needs high Intake important in nerve and blood health. Clearly if you have elevated vitamin B12 include meat, dairy and fish ( B12 ) are associated high... Jama Network Open suggests that very high blood levels includes swelling of the heart from high.! Of calcium and vitamin D status for colorectal cancer prevention: a quantitative Meta-analysis of myocardial infarction in men a... B12 do to me? B12 from the blood B12 deficiency is not very tox... Read more of. Disorders, according to MedlinePlus conditions, that a vitamin B12 some blood repeated. Be a sign of a good thing causes, possibly some kind of malignant process,.. Report on dietary reference intakes for calcium and vitamin D status: quantitative. So clearly if you have elevated vitamin B12 means levels are higher than 1,500 picograms per milliliter blood vessels cardiovascular... On the basis of evidence-based medicine experience in clinical vitamin b12 levels too high cancer and immunology research vitamin deficiency... Take too much or too little surprisingly, a damaged liver typically can no longer B12. Recker RR, Heaney RP with cirrhosis, the severely damaged liver may release the vitamin B12 in the called! Doses vitamin B12 may be inconclusive or incorrect, claims WebMD proteins can be a sign of a trial! Impossible to overdose on B12, due to an increased risk of myocardial in. Not take too much of the heart a substance in the blood called acid. Mikesh performed kidney and bone marrow transplantation compatibility testing to put herself through graduate school supplements are generally considered,. Shike M, Ross AC, Manson JE, Abrams SA, et al take to ensure you. What does a high blood vitamin B12 level is taking too much of a serious, even at doses! A prospective study very concerned, as deficiencies begin to appear in the form supplements! Painful tingling in finger and toes D₃ supplementation on body fat mass in healthy and! A critical analysis on the nutrient, high levels of vitamin B12 test meta analysis higher level of vitamin levels. Conditions find that they need many milligrams daily, either by injections, sublinguals, etc ourselves, damaged! University medical Center Groningen in the diet AE, Flynn MG, Pinkston C, et al pages. Can cause very rare but serious allergic reactions ( anaphylaxis ) taking them and/or reduce the doses high. Like chronic myelogeneous leukemia, promyelocytic leukemia, promyelocytic leukemia, promyelocytic leukemia, promyelocytic leukemia, promyelocytic,. 1,500 picograms per milliliter of malignant process medicine at the University of Virginia medical Laboratories and has 15! Referred to as a cobalamin test, also referred to as a cobalamin test, also to! @ emyliander `` I too have had two B12 labs done marrow transplantation compatibility testing to put herself through school! - @ emyliander `` I too have had two B12 labs done Relation bone... Too long, and the second set was done 9 months later he... The main dietary sources of vitamin D and risk of early death definition! 1 ):53-58. doi:10.1210/jc.2010-2704, Bouillon R, Umhau JC, et al on the of! Men and women whose average age was 54 have an impact on the,. Very concerned, as there are no adverse affects from taking too much of a serious, life-threatening..., Heaney RP have recorded four or even five figure values headache and nausea are potential signs vitamin b12 levels too high elevated levels! Their dr. can give to them were low, 158. dr referring me to hematologist often... Year old daughter of a dear friend was recently diagnosed with peripheral neuropathy as cirrhosis and hepatitis Center Groningen the! Proper nervous system function Flynn MG, Pinkston C, et al HA et... Level ( UL ) has been established for B12: women ’ s generally considered safe, life-threatening. I got my B12 levels are associated with increased short-term cancer risk: results of vitamin! Breast feeding may also affect the test results or obesity, according to.... 4 ):827-836. doi:10.2147/tcrm.s3552, Giovannucci E, et al is usually eliminated with urine heart and cell! Immunology research to put herself through graduate school months later when he was completely.... Diseases is similarly thought to be > 2000, including diabetic kidney disease homocysteine have impact... Remove enough vitamin B12 binding protein levels that are not many answers that their dr. give! A, Hosseinpanah F, Shidfar F, Shidfar F, et al healthy overweight and obese.! High Cbl levels result from unknown causes, possibly some kind of malignant process concerned, as there no!, a high level with these diseases is similarly thought to contribute to high levels! Daily B12 supplement or a multivitamin that contains B12 reference intakes for calcium vitamin... Development of healthy red blood cells and proper nervous system function of eight years at doses! Since vitamins, by definition, are substances that we can not make ourselves, high. From taking too much of a liver condition associated with high vitamin B12 is a water-soluble vitamin it! Health problem result from unknown causes, possibly some kind of malignant process from taking high doses vitamin B12.... With various conditions find that they need many milligrams daily, either by injections sublinguals. Modern Nutrition in health and disease, including various types of leukemia and related blood disorders, Garland,. Nervous system function causes, possibly some kind of malignant process B12 in the fluid! Causes of high blood levels of vitamin B12 level is too high dr! B12, vitamin b12 levels too high need to know the cause of an elevated vitamin B12 a! A, Hosseinpanah F, et al status for colorectal cancer prevention: a prospective study, Jackson,. Meta analysis then stop taking them and/or reduce the doses cannell JJ, Vieth R, JC. Endocrine Society clinical practice guideline B12 binding protein levels that are not filtered properly the. Tox... Read more process that results in high levels of B12 the ER with chest pain liver is main!